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GSH is the major cellular antioxidant which maintaining redox homeostasis from the following two aspects: bind to ferrous iron in the labile iron pool (LIP) to prevent the iron-dependent oxidization (Hider and Kong, 2011) and as the substrate of GPX4-mediate lipid detoxification (Friedmann Angeli et al., 2014

In that study, the administration of ginkgo extract resulted in faster recovery of balance and improved neuronal connectivity following acute inner ear damage

Similar findings have been reported in the peripheral immune system, with peripheral blood mononuclear cells (PBMCs) from individuals with iPD exhibiting increased glycolytic activity, capacity, and reserve relative to controls [30]

High circulating ADM was strongly associated with disease severity, organ failure, vasopressor need, and 30-day mortality, highlighting its value as both a biomarker and predictor of outcome in septic patients (Lundberg et al., 2020)

The principal regulator of glutamine utilization is the transcription factor c-myc , which is often upregulated in proliferating cells [17,18]

In addition, other epigenetic signals have been observed in mitochondria, in particular the interaction between mtDNA methylation and non-coding RNAs